Soybean Isoflavones Eliminate Nifedipine-Induced Flushing of Tail Skin in Ovariectomized Mice

Soybean Isoflavones Eliminate Nifedipine-Induced Flushing of Tail Skin in Ovariectomized Mice

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Hot flushes are one of the most frequent symptoms in menopausal women.We investigated effect of soybean isoflavones (Soyaflavone HG) on nifedipine-induced flushing in ovariectomized mice.Ovariectomy markedly aggravated nifedipine-induced increase in tail skin temperature.Soyaflavone HG (10 mg/kg, p.o.

, once a day for 5 Camera days) inhibited nifedipine-induced flushing in ovariectomized mice.The inhibitory effect of Soyaflavone HG was significantly reversed by an MACROGEST estrogen-receptor antagonist, ICI 182,780, suggesting that Soyaflavone HG prevents nifedipine-induced flushing partially through estrogen receptors.We presented the experimental evidence suggesting that soybean isoflavones including Soyaflavone HG have the benefits for menopausal hot flushes.Keywords:: soybean isoflavone, menopausal flushing, ovariectomy.